Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2001-8-16
pubmed:abstractText
Oestrogen/oestrogen receptor (ER) and vitamin D/vitamin D receptor (VDR) systems have been implicated in the pathogenesis of colorectal cancers. The expression of erbB-2 and epidermal growth factor receptor (EGFR) in colorectal cancers has been suggested to have diagnostic and prognostic significance. In our study, XbaI and PvuII polymorphisms of the ER gene and the BsmI polymorphism of the VDR gene were studied in 56 Caucasian patients with rectal cancer. The relationship between the ER and VDR genotypes and the expression of oncogenes was also investigated. The presence of the x allele of ER gene significantly correlated with the overexpression of the erbB-2 and EGFR oncogenes. Significantly increased erbB-2 expression was observed in patients with the VDR B allele. The XXbb allelic combination of the ER/VDR genes was associated with a significantly lower erbB-2 expression, whereas in the other genotypes significantly higher oncogene expression was seen. Our data raise the possibility that ER/VDR gene polymorphisms accompanied by variable oncogene expression might influence the pathogenetic processes of colorectal cancers.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0959-8049
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1463-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11506951-Adult, pubmed-meshheading:11506951-Aged, pubmed-meshheading:11506951-Aged, 80 and over, pubmed-meshheading:11506951-Alleles, pubmed-meshheading:11506951-Female, pubmed-meshheading:11506951-Gene Expression, pubmed-meshheading:11506951-Genes, erbB-2, pubmed-meshheading:11506951-Humans, pubmed-meshheading:11506951-Male, pubmed-meshheading:11506951-Middle Aged, pubmed-meshheading:11506951-Polymorphism, Genetic, pubmed-meshheading:11506951-Polymorphism, Restriction Fragment Length, pubmed-meshheading:11506951-Receptor, Epidermal Growth Factor, pubmed-meshheading:11506951-Receptor, erbB-2, pubmed-meshheading:11506951-Receptors, Calcitriol, pubmed-meshheading:11506951-Receptors, Estrogen, pubmed-meshheading:11506951-Rectal Neoplasms, pubmed-meshheading:11506951-Restriction Mapping
pubmed:year
2001
pubmed:articleTitle
Oestrogen and vitamin D receptor (VDR) genotypes and the expression of ErbB-2 and EGF receptor in human rectal cancers.
pubmed:affiliation
1st Department of Medicine, Semmelweis University Budapest, Korányi 2/a, Budapest H-1083, Hungary.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't