Source:http://linkedlifedata.com/resource/pubmed/id/11506704
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2001-8-16
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| pubmed:abstractText |
We describe the molecular cloning and characterization of LZ-FYVE, a novel embryonic factor that possesses two leucine zipper motifs and a FYVE-finger domain. A partial clone of LZ-FYVE, encoding a functional leucine zipper domain, was initially isolated from a mouse embryo cDNA library by virtue of its interaction in the yeast two-hybrid system with the transcription factor ATF-2. The LZ-FYVE protein demonstrated mouse embryo-specific expression by Northern blot analysis and was detected as a nuclear protein at very restricted periods (12--14 days post-coitus) in specific tissues during embryogenesis. In particular, LZ-FYVE protein was notable in embryonic lung, cartilage, and otic capsule. Structural analysis of the deduced, full-length LZ-FYVE amino acid sequence revealed two N-terminal leucine zipper domains as well as a C-terminal FYVE-finger domain. The FYVE-finger domains specifically recognized phosphatidylinositol 3-phosphate and have been previously described only in cytoplasmic proteins involved in endosomal membrane fusion, vesicular trafficking, or organelle-specific targeting. While LZ-FYVE may have endosomal functions in the cytoplasm, because LZ-FYVE is present in the nucleus at early stages of embryonic development, it is likely that LZ-FYVE has a nuclear function.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Activating Transcription Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Atf2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
1044-5498
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
403-12
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11506704-Activating Transcription Factor 2,
pubmed-meshheading:11506704-Amino Acid Sequence,
pubmed-meshheading:11506704-Animals,
pubmed-meshheading:11506704-Base Sequence,
pubmed-meshheading:11506704-Blotting, Northern,
pubmed-meshheading:11506704-Cell Differentiation,
pubmed-meshheading:11506704-Cell Line,
pubmed-meshheading:11506704-Chondrocytes,
pubmed-meshheading:11506704-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:11506704-Gene Expression,
pubmed-meshheading:11506704-HeLa Cells,
pubmed-meshheading:11506704-Humans,
pubmed-meshheading:11506704-Leucine Zippers,
pubmed-meshheading:11506704-Mice,
pubmed-meshheading:11506704-Mice, Inbred C3H,
pubmed-meshheading:11506704-Molecular Sequence Data,
pubmed-meshheading:11506704-Nuclear Proteins,
pubmed-meshheading:11506704-Stem Cells,
pubmed-meshheading:11506704-Transcription Factors
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| pubmed:year |
2001
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| pubmed:articleTitle |
LZ-FYVE: a novel developmental stage-specific leucine zipper, FYVE-finger protein.
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| pubmed:affiliation |
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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