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pubmed-article:11505018pubmed:abstractTextSerotonergic (5-HT) dysfunction has been implicated in the etiology of both behavioral disinhibition (BD) and negative affect (NA). This work extends our previous finding of relationships between whole blood 5-HT and both BD and NA in pubescent, but not prepubescent, children of alcoholics and continues examination of a hypothesized role of 5-HT dysfunction in alcoholism risk. The long and short (L and S) variants of the 5-HT transporter gene-linked polymorphic region (5-HTTLPR) are responsible for differing transcriptional efficiencies in 5-HT uptake. Although associations have been found between the SS 5-HTTLPR genotype and severe alcoholism and neuroticism, recent reports describe relationships between the LL genotype and both low level of response to alcohol and alcoholism diagnosis and a predominance of the LL genotype in early-onset alcoholics.lld:pubmed
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pubmed-article:11505018pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:11505018pubmed:year2001lld:pubmed
pubmed-article:11505018pubmed:articleTitleSerotonin transporter promoter polymorphism genotype is associated with behavioral disinhibition and negative affect in children of alcoholics.lld:pubmed
pubmed-article:11505018pubmed:affiliationIntegrated Substance Abuse Programs (GRT), University of California, Los Angeles, California 90025, USA. twitche2@ucla.edulld:pubmed
pubmed-article:11505018pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:11505018pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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