Source:http://linkedlifedata.com/resource/pubmed/id/11504301
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2001-8-15
|
| pubmed:abstractText |
Genetic epidemiology provides data on cancer etiology, familial risks and genotype-specific risks. These data are useful for clinical counselling and gene identification. The studies require large, unbiased sample sizes and collaboration between research teams, nationally and internationally. A recent study on Nordic twins suggests that in colorectal, breast and prostate cancer, the inherited component ranges between 27 and 42%, far in excess of the known susceptibility genes. The data from the Swedish Family-Cancer Database, particularly on second cancers, also suggest that a main genetic component in cancer is polygenic. The results have implications for design of genetic studies and for clinical counselling.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0284-186X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
439-44
|
| pubmed:dateRevised |
2009-5-12
|
| pubmed:meshHeading |
pubmed-meshheading:11504301-Case-Control Studies,
pubmed-meshheading:11504301-Cocarcinogenesis,
pubmed-meshheading:11504301-Databases, Factual,
pubmed-meshheading:11504301-Environment,
pubmed-meshheading:11504301-Ethics, Medical,
pubmed-meshheading:11504301-Genetic Counseling,
pubmed-meshheading:11504301-Genetic Predisposition to Disease,
pubmed-meshheading:11504301-Humans,
pubmed-meshheading:11504301-Neoplasms,
pubmed-meshheading:11504301-Neoplasms, Second Primary,
pubmed-meshheading:11504301-Neoplastic Syndromes, Hereditary,
pubmed-meshheading:11504301-Nuclear Family,
pubmed-meshheading:11504301-Parents,
pubmed-meshheading:11504301-Registries,
pubmed-meshheading:11504301-Risk,
pubmed-meshheading:11504301-Scandinavia,
pubmed-meshheading:11504301-Sweden,
pubmed-meshheading:11504301-Twin Studies as Topic
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Genetic Epidemiology--science and ethics on familial cancers.
|
| pubmed:affiliation |
Department of Biosciences, Karolinska Institute, Huddinge, Sweden. kari.hemminki@cnt.ki.se
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Review,
Research Support, Non-U.S. Gov't
|