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rdf:type |
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lifeskim:mentions |
umls-concept:C0018270,
umls-concept:C0030705,
umls-concept:C0034052,
umls-concept:C0040690,
umls-concept:C0053932,
umls-concept:C0152171,
umls-concept:C0205349,
umls-concept:C0871261,
umls-concept:C1135918,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
7
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pubmed:dateCreated |
2001-8-14
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pubmed:abstractText |
Mutations in the type II receptor for bone morphogenetic protein (BMPR-II), a receptor member of the transforming growth factor-beta (TGF-beta) superfamily, underlie many cases of familial and sporadic primary pulmonary hypertension (PPH). We postulated that pulmonary artery smooth muscle cells (PASMCs) from patients with PPH might demonstrate abnormal growth responses to TGF-beta superfamily members.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Activin Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/BMPR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cross-Linking Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidine,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/transforming growth factor-beta...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
790-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11502704-Activin Receptors,
pubmed-meshheading:11502704-Adult,
pubmed-meshheading:11502704-Binding, Competitive,
pubmed-meshheading:11502704-Bone Morphogenetic Protein Receptors, Type II,
pubmed-meshheading:11502704-Bone Morphogenetic Proteins,
pubmed-meshheading:11502704-Cell Division,
pubmed-meshheading:11502704-Cells, Cultured,
pubmed-meshheading:11502704-Cross-Linking Reagents,
pubmed-meshheading:11502704-DNA,
pubmed-meshheading:11502704-DNA Mutational Analysis,
pubmed-meshheading:11502704-Female,
pubmed-meshheading:11502704-Gene Expression Profiling,
pubmed-meshheading:11502704-Humans,
pubmed-meshheading:11502704-Hypertension, Pulmonary,
pubmed-meshheading:11502704-Male,
pubmed-meshheading:11502704-Middle Aged,
pubmed-meshheading:11502704-Muscle, Smooth, Vascular,
pubmed-meshheading:11502704-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11502704-Pulmonary Artery,
pubmed-meshheading:11502704-RNA, Messenger,
pubmed-meshheading:11502704-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:11502704-Signal Transduction,
pubmed-meshheading:11502704-Thymidine,
pubmed-meshheading:11502704-Transforming Growth Factor beta,
pubmed-meshheading:11502704-Transforming Growth Factor beta1
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pubmed:year |
2001
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pubmed:articleTitle |
Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins.
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pubmed:affiliation |
Department of Medicine, University of Cambridge, Addenbrooke's and Papworth Hospitals, Cambridge, United Kingdom. nwm23@cam.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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