Estrogen has been found to increase the risk of deep vein thrombosis (DVT), which is associated with venous ulcers. A matched case-control study was therefore performed to quantify the effect of hormone replacement therapy (HRT) on the occurrence of venous ulcers of the lower limbs.
Montefiore Medical Center, Albert Einstein College of Medicine, Departments of Emergency Medicine and of Epidemiology, Bronx, NY, USA. berard@aecom.yu.edu