Linked Life Data

11499900

Source:http://linkedlifedata.com/resource/pubmed/id/11499900

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-8-13
pubmed:abstractText
Functional magnetic resonance imaging (fMRI), a still-emerging, non-invasive neuroimaging tool, has been applied to a wide range of questions in sensory, motor control, and cognitive psychology. Only more recently has it been applied to understand the sites and mechanisms of action of pharmacological agents within the human CNS. However, in so doing, a new set of problems and concerns surrounding the technique must be addressed because of the unique transduction mechanisms (both physiological and biophysical) that exist to produce the fMRI signal from the underlying neuronal activity. Experimental design and control issues become paramount in performing fMRI pharmacological protocols and in signal interpretation. With these caveats, the use of pharmacological agents with fMRI is likely to greatly increase in the near term as new questions about both brain physiology and neuropharmacological mechanisms become addressable for the first time. Examples are given using nicotine and cocaine as a prototypical agents.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0146-4760
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
419-24
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
fMRI: a new tool for the in vivo localization of drug actions in the brain.
pubmed:affiliation
Department of Psychiatry, Medical College of Wisconsin, Milwaukee 53226, USA. estein@mcw.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review