11497260

Source:http://linkedlifedata.com/resource/pubmed/id/11497260

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0086418, umls-concept:C0162638, umls-concept:C0205263, umls-concept:C0281361, umls-concept:C0532362, umls-concept:C0667830, umls-concept:C0950968, umls-concept:C1510779
pubmed:issue	3B
pubmed:dateCreated	2001-8-10
pubmed:abstractText	Irofulven (MGI 114) is a novel, clinically active sesquiterpene whose mechanism of action is not fully understood. We sought to identify apoptotic effectors induced by this agent in human pancreatic cancer cells.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/K12CA01723-07
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8102988
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Chloromethyl Ketones, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating, http://linkedlifedata.com/resource/pubmed/chemical/CASP8 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CASP9 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8, http://linkedlifedata.com/resource/pubmed/chemical/Caspase 9, http://linkedlifedata.com/resource/pubmed/chemical/Caspases, http://linkedlifedata.com/resource/pubmed/chemical/Coloring Agents, http://linkedlifedata.com/resource/pubmed/chemical/DAPI, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Propidium, http://linkedlifedata.com/resource/pubmed/chemical/Sesquiterpenes, http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts, http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles, http://linkedlifedata.com/resource/pubmed/chemical/benzyloxycarbonylvalyl-alanyl-aspart..., http://linkedlifedata.com/resource/pubmed/chemical/irofulven, http://linkedlifedata.com/resource/pubmed/chemical/thiazolyl blue
pubmed:status	MEDLINE
pubmed:issn	0250-7005
pubmed:author	pubmed-author:MacDonaldJ RJR, pubmed-author:MillerA RAR, pubmed-author:StrodelW EWE, pubmed-author:Von HoffD DDD, pubmed-author:WantDD, pubmed-author:WatersS JSJ
pubmed:issnType	Print
pubmed:volume	21
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1789-94
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:11497260-Amino Acid Chloromethyl Ketones, pubmed-meshheading:11497260-Antineoplastic Agents, Alkylating, pubmed-meshheading:11497260-Apoptosis, pubmed-meshheading:11497260-Blotting, Western, pubmed-meshheading:11497260-Caspase 8, pubmed-meshheading:11497260-Caspase 9, pubmed-meshheading:11497260-Caspases, pubmed-meshheading:11497260-Coloring Agents, pubmed-meshheading:11497260-DNA Fragmentation, pubmed-meshheading:11497260-Enzyme Inhibitors, pubmed-meshheading:11497260-Flow Cytometry, pubmed-meshheading:11497260-Humans, pubmed-meshheading:11497260-Immunoblotting, pubmed-meshheading:11497260-In Situ Nick-End Labeling, pubmed-meshheading:11497260-Indoles, pubmed-meshheading:11497260-Inhibitory Concentration 50, pubmed-meshheading:11497260-Pancreatic Neoplasms, pubmed-meshheading:11497260-Propidium, pubmed-meshheading:11497260-Sesquiterpenes, pubmed-meshheading:11497260-Tetrazolium Salts, pubmed-meshheading:11497260-Thiazoles, pubmed-meshheading:11497260-Tumor Cells, Cultured
pubmed:articleTitle	Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells.
pubmed:affiliation	Department of Surgery, University of Texas Health Science Center at San Antonio, 78229, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't