| pubmed-article:11495908 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11495908 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:11495908 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:11495908 | lifeskim:mentions | umls-concept:C1538768 | lld:lifeskim |
| pubmed-article:11495908 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:11495908 | pubmed:issue | 42 | lld:pubmed |
| pubmed-article:11495908 | pubmed:dateCreated | 2001-10-15 | lld:pubmed |
| pubmed-article:11495908 | pubmed:abstractText | Rab11a is a small GTP-binding protein enriched in the pericentriolar plasma membrane recycling systems. We hypothesized that Rab11a-binding proteins exist as downstream effectors of its action. Here we define a family of four Rab11-interacting proteins: Rab11-Family Interacting Protein 1 (Rab11-FIP1), Rab11-Family Interacting Protein 2 (Rab11-FIP2), Rab11-Family Interacting Protein 3 (Rab11-FIP3), and pp75/Rip11. All four interacting proteins associated with wild type Rab11a and dominant active Rab11a (Rab11aS20V) as well as Rab11b and Rab25. Rab11-FIP2 also interacted with dominant negative Rab11a (Rab11aS25N) and the tail of myosin Vb. The binding of Rab11-FIP1, Rab11-FIP2, and Rab11-FIP3 to Rab11a was dependent upon a conserved carboxyl-terminal amphipathic alpha-helix. Rab11-FIP1, Rab11-FIP2, and pp75/Rip11 colocalized with Rab11a in plasma membrane recycling systems in both non-polarized HeLa cells and polarized Madin-Darby canine kidney cells. GFP-Rab11-FIP3 also colocalized with Rab11a in HeLa cells. Rab11-FIP1, Rab11-FIP2, and pp75/Rip11 also coenriched with Rab11a and H(+)K(+)-ATPase on parietal cell tubulovesicles, and Rab11-FIP1 and Rab11-FIP2 translocated with Rab11a and the H(+)K(+)-ATPase upon stimulating parietal cells with histamine. The results suggest that the function of Rab11a in plasma membrane recycling systems is dependent upon a compendium of protein effectors. | lld:pubmed |
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| pubmed-article:11495908 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11495908 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11495908 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11495908 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11495908 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11495908 | pubmed:author | pubmed-author:KumarRR | lld:pubmed |
| pubmed-article:11495908 | pubmed:author | pubmed-author:HardyDD | lld:pubmed |
| pubmed-article:11495908 | pubmed:author | pubmed-author:ChanE KEK | lld:pubmed |
| pubmed-article:11495908 | pubmed:author | pubmed-author:GoldenringJ... | lld:pubmed |
| pubmed-article:11495908 | pubmed:author | pubmed-author:HaleyC SCS | lld:pubmed |
| pubmed-article:11495908 | pubmed:author | pubmed-author:LapierreL ALA | lld:pubmed |
| pubmed-article:11495908 | pubmed:author | pubmed-author:Hobdy-Henders... | lld:pubmed |
| pubmed-article:11495908 | pubmed:author | pubmed-author:NavarreJJ | lld:pubmed |
| pubmed-article:11495908 | pubmed:author | pubmed-author:GrinerRR | lld:pubmed |
| pubmed-article:11495908 | pubmed:author | pubmed-author:DornM CMC | lld:pubmed |
| pubmed-article:11495908 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11495908 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:11495908 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11495908 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11495908 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11495908 | pubmed:pagination | 39067-75 | lld:pubmed |
| pubmed-article:11495908 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11495908 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11495908 | pubmed:articleTitle | Identification and characterization of a family of Rab11-interacting proteins. | lld:pubmed |
| pubmed-article:11495908 | pubmed:affiliation | Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia and the Augusta Veterans Affairs Medical Center, Augusta, Georgia 30912, USA. | lld:pubmed |
| pubmed-article:11495908 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11495908 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11495908 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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