11495636

Source:http://linkedlifedata.com/resource/pubmed/id/11495636

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0030685, umls-concept:C0218111, umls-concept:C0242692, umls-concept:C0391871, umls-concept:C0521116, umls-concept:C0596235, umls-concept:C0680255, umls-concept:C1283071, umls-concept:C1709059, umls-concept:C1711351, umls-concept:C1879547, umls-concept:C1963578
pubmed:dateCreated	2003-10-29
pubmed:abstractText	The multisubunit (alpha1S,alpha2-delta, beta1a and gamma1) skeletal muscle dihydropyridine receptor (DHPR) transduces membrane depolarization into release of Ca2+ from the sarcoplasmic reticulum (SR) and also acts as an L-type Ca2+ channel. To more fully investigate the function of the gamma1 subunit in these two processes, we produced mice lacking this subunit by gene targeting.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AR46448, http://linkedlifedata.com/resource/pubmed/grant/HL-47053
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101088687
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels, L-Type, http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits
pubmed:status	MEDLINE
pubmed:issn	1472-6793
pubmed:author	pubmed-author:AhernC ACA, pubmed-author:BiddlecomeG HGH, pubmed-author:CampbellK PKP, pubmed-author:CoronadoRR, pubmed-author:GreggR GRG, pubmed-author:MortensonLL, pubmed-author:PowersP APA, pubmed-author:RoetheLL, pubmed-author:StrubeCC, pubmed-author:VallejoPP
pubmed:issnType	Electronic
pubmed:volume	1
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	8
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:11495636-Animals, pubmed-meshheading:11495636-Calcium, pubmed-meshheading:11495636-Calcium Channels, L-Type, pubmed-meshheading:11495636-Cells, Cultured, pubmed-meshheading:11495636-Electric Conductivity, pubmed-meshheading:11495636-Gene Targeting, pubmed-meshheading:11495636-Mice, pubmed-meshheading:11495636-Muscle, Skeletal, pubmed-meshheading:11495636-Muscle Fibers, Skeletal, pubmed-meshheading:11495636-Myocardial Contraction, pubmed-meshheading:11495636-Patch-Clamp Techniques, pubmed-meshheading:11495636-Protein Subunits
pubmed:year	2001
pubmed:articleTitle	Modulation of L-type Ca2+ current but not activation of Ca2+ release by the gamma1 subunit of the dihydropyridine receptor of skeletal muscle.
pubmed:affiliation	Department of Physiology, University of Wisconsin School of Medicine, Madison, WI 53706, USA. cahern@physiology.wisc.edu

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