Linked Life Data

11494360

Source:http://linkedlifedata.com/resource/pubmed/id/11494360

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-8-8
pubmed:abstractText
1-Methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-exposed cats develop severe Parkinsonism that spontaneously resolves in 4-6 weeks. The present study examined the extent to which compensatory changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) gene and protein expression may underlie this behavioral recovery. In normal cats, TH and DAT protein levels were higher in the dorsal vs. ventral striatum. Expression of DAT and TH mRNA was higher in substantia nigra pars compacta (SNc) than in the ventral tegmental area (VTA). In symptomatic parkinsonian animals, DAT and TH protein levels were significantly decreased in all striatal areas studied. TH and DAT mRNA expression in residual SNc neurons were decreased a mean 32% and 38%, respectively. DAT gene expression in residual VTA neurons in symptomatic animals was decreased 30% whereas TH gene expression was unaffected. In spontaneously recovered cats, TH protein levels were significantly higher than the levels in symptomatic cats only in the ventral striatum, whereas no increase in DAT protein levels were observed in any striatal area. Residual neurons in most ventral mesencephalic regions of recovered cats had increased TH mRNA expression but not increased DAT gene expression, compared with symptomatic animals. Thus, increased TH protein and mRNA and suppression of DAT protein and mRNA expression in the striatum and ventral mesencephalon were associated with functional recovery from MPTP-induced parkinsonism.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0360-4012
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
254-66
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11494360-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, pubmed-meshheading:11494360-Animals, pubmed-meshheading:11494360-Carrier Proteins, pubmed-meshheading:11494360-Cats, pubmed-meshheading:11494360-Corpus Striatum, pubmed-meshheading:11494360-Dopamine, pubmed-meshheading:11494360-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:11494360-Female, pubmed-meshheading:11494360-Gene Expression Profiling, pubmed-meshheading:11494360-In Situ Hybridization, pubmed-meshheading:11494360-Male, pubmed-meshheading:11494360-Membrane Glycoproteins, pubmed-meshheading:11494360-Membrane Transport Proteins, pubmed-meshheading:11494360-Mesencephalon, pubmed-meshheading:11494360-Nerve Tissue Proteins, pubmed-meshheading:11494360-Neurons, pubmed-meshheading:11494360-Parkinsonian Disorders, pubmed-meshheading:11494360-RNA, Messenger, pubmed-meshheading:11494360-Remission, Spontaneous, pubmed-meshheading:11494360-Tyrosine 3-Monooxygenase
pubmed:year
2001
pubmed:articleTitle
Tyrosine hydroxylase and dopamine transporter expression in residual dopaminergic neurons: potential contributors to spontaneous recovery from experimental Parkinsonism.
pubmed:affiliation
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.