Source:http://linkedlifedata.com/resource/pubmed/id/11493462
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2001-8-8
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| pubmed:abstractText |
The polarization of the immune response toward a Th2 or a Th1 profile can be mediated by dendritic cells (DCs) following antigen presentation and interaction with T cells. Costimulatory molecules such as CD80 and CD86 expressed by DCs, the polarizing cytokine environment during DC--T-cell interaction, and also the nature of the antigen are critical in the orientation of the immune response. In this study, the effect of the cysteine protease Der p 1, one of the major allergens of the house dust mite Dermatophagoides pteronyssinus, on these different parameters was evaluated comparatively on monocyte-derived DCs obtained from healthy donors, from pollen-sensitive patients, or from patients sensitive to Dermatophagoides pteronyssinus. Results showed that Der p 1 induced an increase in CD86 expression only on DCs from house dust mite--sensitive patients. This was also associated with a higher capacity to induce T-cell proliferation, a rapid increase in the production of proinflammatory cytokines, tumor necrosis factor--alpha and interleukin (IL)-1 beta, and the type 2 cytokine IL-10. No changes in the release of IL-12 p70 were induced by Der p 1. Finally, purified T cells from house dust mite-sensitive patients stimulated by autologous Der p 1--pulsed DCs preferentially produced IL-4 rather than interferon-gamma. These effects were abolished in the presence of the inactive precursor of Der p 1 (ProDer p 1). Taken together, these data suggest that DCs from house dust mite--sensitive patients, in contrast to DCs from healthy donors and from pollen-sensitive patients, exposed to Der p 1 play a pivotal role in the enhancement of the Th2 response associated with the allergic reaction developed in response to house dust mite exposure. (Blood. 2001;98:1135-1141)
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Dermatophagoides,
http://linkedlifedata.com/resource/pubmed/chemical/CD83 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CD86 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0006-4971
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
98
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1135-41
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| pubmed:dateRevised |
2005-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11493462-Animals,
pubmed-meshheading:11493462-Antigens, CD,
pubmed-meshheading:11493462-Antigens, CD80,
pubmed-meshheading:11493462-Antigens, CD86,
pubmed-meshheading:11493462-Antigens, Dermatophagoides,
pubmed-meshheading:11493462-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11493462-Case-Control Studies,
pubmed-meshheading:11493462-Cell Differentiation,
pubmed-meshheading:11493462-Coculture Techniques,
pubmed-meshheading:11493462-Cytokines,
pubmed-meshheading:11493462-Dendritic Cells,
pubmed-meshheading:11493462-Glycoproteins,
pubmed-meshheading:11493462-Humans,
pubmed-meshheading:11493462-Hypersensitivity,
pubmed-meshheading:11493462-Immunoglobulins,
pubmed-meshheading:11493462-Lymphocyte Activation,
pubmed-meshheading:11493462-Membrane Glycoproteins,
pubmed-meshheading:11493462-Mites,
pubmed-meshheading:11493462-Monocytes,
pubmed-meshheading:11493462-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:11493462-Th2 Cells
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| pubmed:year |
2001
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| pubmed:articleTitle |
Th2 polarization by Der p 1--pulsed monocyte-derived dendritic cells is due to the allergic status of the donors.
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| pubmed:affiliation |
Unité INSERM U416, IFR 17, Institut Pasteur de Lille, France.
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| pubmed:publicationType |
Journal Article
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