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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1975-11-6
|
| pubmed:abstractText |
Veratrum alkaloids injected into the coronary circulation stimulate myocardial receptors to produce reflex bradycardia and arterial hypotension (the Bezold-Jarisch reflex). This study investigated the hypothesis that parasympathetic coronary vasodilation occurs as part of the Bezold-Jarisch reflex. Blood flow in the circumflex coronary artery was measured in chloralose-anesthetized, closed-chest dogs with a newly developed cannula-tip flow transducer. Alpha-receptor blockade with Dibozane (2 mg/kg) was used to prevent peripheral vasodilation, and beta-receptor blockade with propranolol (1 mg/kg) was used to prevent adrenergic cardiac effects. Electrical pacing was used to maintain a constant heart rate. Under these conditions, veratridine injected into the anterior descending coronary artery but not into the circumflex coronary artery produced a 63% increase in circumflex coronary blood flow and an 88% increase in diastolic coronary conductance. The effect was abolished when the reflex arc was interrupted by either vagotomy or atropine administration. It is concluded that a cardiocoronary reflex parasympathetic coronary vasodilation can be elicited by stimulating cardiac receptors with veratridine.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0009-7330
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
175-82
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1149191-Animals,
pubmed-meshheading:1149191-Blood Pressure,
pubmed-meshheading:1149191-Bradycardia,
pubmed-meshheading:1149191-Coronary Circulation,
pubmed-meshheading:1149191-Coronary Vessels,
pubmed-meshheading:1149191-Dogs,
pubmed-meshheading:1149191-Electrocardiography,
pubmed-meshheading:1149191-Heart,
pubmed-meshheading:1149191-Heart Rate,
pubmed-meshheading:1149191-Male,
pubmed-meshheading:1149191-Myocardial Contraction,
pubmed-meshheading:1149191-Myocardium,
pubmed-meshheading:1149191-Oxygen Consumption,
pubmed-meshheading:1149191-Pacemaker, Artificial,
pubmed-meshheading:1149191-Parasympathetic Nervous System,
pubmed-meshheading:1149191-Propranolol,
pubmed-meshheading:1149191-Reflex,
pubmed-meshheading:1149191-Respiratory Insufficiency,
pubmed-meshheading:1149191-Vagus Nerve,
pubmed-meshheading:1149191-Vasomotor System,
pubmed-meshheading:1149191-Veratridine
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
Reflex parasympathetic coronary vasodilation elicited from cardiac receptors in the dog.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|