Source:http://linkedlifedata.com/resource/pubmed/id/11489978
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2001-8-7
|
| pubmed:abstractText |
Lung fibrosis is an important pulmonary disease with a high mortality rate, but its pathophysiological mechanism has not been fully clarified. Various types of cells have been implicated in the development of lung fibrosis, including T cells. However, the contribution of functional molecules expressed on T cells to the development of lung fibrosis remains largely unknown. In this study, we determined whether costimulation via CD28 on T cells was crucial for the development of lung fibrosis by intratracheally administering bleomycin into CD28-deficient mice. Compared with wild-type mice, the CD28-deficient mice showed markedly impaired lung fibrosis after injection with low doses of bleomycin, as judged by histological changes and hydroxyproline content in the lungs. In addition, bleomycin-induced T cell infiltration into the airways and production of several cytokines and chemokines including IL-5 were also impaired in the CD28-deficient mice. Furthermore, adoptive transfer of CD28-positive T cells from wild-type mice recovered the impaired bleomycin-induced lung fibrosis in CD28-deficient mice. These findings suggest that the CD28-mediated T cell costimulation plays a critical role in the development of lung fibrosis, possibly by regulating the production of cytokines and chemokines in the lung. Thus, manipulation of the CD28-mediated costimulation could be a potential therapeutic strategy for the prevention of lung fibrosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Bleomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
167
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1977-81
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11489978-Adoptive Transfer,
pubmed-meshheading:11489978-Animals,
pubmed-meshheading:11489978-Antigens, CD,
pubmed-meshheading:11489978-Antigens, CD28,
pubmed-meshheading:11489978-Antigens, CD86,
pubmed-meshheading:11489978-Bleomycin,
pubmed-meshheading:11489978-Cell Movement,
pubmed-meshheading:11489978-Chemokines,
pubmed-meshheading:11489978-Cytokines,
pubmed-meshheading:11489978-Dose-Response Relationship, Drug,
pubmed-meshheading:11489978-Female,
pubmed-meshheading:11489978-Intubation, Intratracheal,
pubmed-meshheading:11489978-Lymphocytes,
pubmed-meshheading:11489978-Macrophages, Alveolar,
pubmed-meshheading:11489978-Membrane Glycoproteins,
pubmed-meshheading:11489978-Mice,
pubmed-meshheading:11489978-Mice, Inbred C57BL,
pubmed-meshheading:11489978-Mice, Knockout,
pubmed-meshheading:11489978-Neutrophils,
pubmed-meshheading:11489978-Pulmonary Fibrosis,
pubmed-meshheading:11489978-T-Lymphocyte Subsets
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice.
|
| pubmed:affiliation |
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|