Source:http://linkedlifedata.com/resource/pubmed/id/11489754
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2001-8-7
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| pubmed:abstractText |
Microsomal epoxide hydrolase (mEH) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke and cooked meat. Polymorphisms in exon 3 and exon 4 of the mEH gene have been found to alter mEH activity. We investigated the association between these polymorphisms and colorectal polyps within the Minnesota Cancer Prevention Research Unit case-control study. Cases were diagnosed with colonoscopically confirmed adenomas (n = 530) or hyperplastic polyps (n = 202); controls (n = 649) were polyp-free at colonoscopy. Smoking history and meat consumption were obtained from self-administered questionnaires before colonoscopy. mEH genotypes were determined by PCR/RFLP or oligonucleotide ligation assay. The overall risks associated with exon 3 or exon 4 polymorphisms for both adenomas and hyperplastic polyps were not statistically different from 1.0. Compared with exon 3 Tyr/Tyr, 0 pack-years, risk was highest among those with the exon 3 His/His genotype and >25 pack-years of smoking [adenoma, odds ratio (OR) = 4.9 (1.9-12.8); hyperplastic, OR = 7.7 (2.5-24.0)]. Risks were not elevated among exon 4 homozygous variants, even in the presence of heavy smoking. Fried, baked, or broiled meat intake of > or =two servings/week (high) compared with < or =one serving/week was associated with a 2-fold increase in risk of adenoma. The highest risks were seen for those with the exon 3 His/His genotype and high cooked meat intake [OR = 3.3 (1.4-7.9); reference group: Tyr/Tyr, < or = 1 serving/week). Although mEH polymorphisms are not associated with an increased risk of colorectal polyps overall, genotypes that produce a slow phenotype appear to be associated with an increased risk in the presence of smoking and high intakes of cooked meat.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
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| pubmed:issn |
1055-9965
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
875-82
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:11489754-Adult,
pubmed-meshheading:11489754-Aged,
pubmed-meshheading:11489754-Case-Control Studies,
pubmed-meshheading:11489754-Colonic Polyps,
pubmed-meshheading:11489754-Cooking,
pubmed-meshheading:11489754-Diet,
pubmed-meshheading:11489754-Epoxide Hydrolases,
pubmed-meshheading:11489754-Female,
pubmed-meshheading:11489754-Genotype,
pubmed-meshheading:11489754-Histamine,
pubmed-meshheading:11489754-Humans,
pubmed-meshheading:11489754-Male,
pubmed-meshheading:11489754-Meat,
pubmed-meshheading:11489754-Middle Aged,
pubmed-meshheading:11489754-Odds Ratio,
pubmed-meshheading:11489754-Polymorphism, Genetic,
pubmed-meshheading:11489754-Risk Factors,
pubmed-meshheading:11489754-Smoking,
pubmed-meshheading:11489754-Tyrosine
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Epoxide hydrolase Tyr113His polymorphism is associated with elevated risk of colorectal polyps in the presence of smoking and high meat intake.
|
| pubmed:affiliation |
Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington 98109-1024, USA. nulrich@fhcrc.org
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| pubmed:publicationType |
Journal Article
|