Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-5-24
pubmed:abstractText
The primary objective of the study was to determine the effect of levodopa (LD) on human substantia nigra. The study included patients seen at the Movement Disorder Clinic, Saskatoon over a 32 year period. The evidence provided is based on epidemiological observations of 934 consecutive Parkinson syndrome (PS) patients assessed during 22 years and detailed studies of six patients including two autopsies. Life expectancy increased significantly with LD therapy. The prolonged survival was evident when the patients were treated during early stage of the illness. One parkinsonian patient with substantia nigra (SN) pathology who was extensively studied for 30 years, revealed significant slowing of the disease progression while on LD. Three essential tremor patients who received 24 kg (26 years), 22 kg (21.5 years), and 8.5 kg (12.5 years) LD respectively, had no evidence of PS and one autopsy revealed normal SN. Two dopa-responsive dystonia patients who received LD 3 kg (11 years) and 17 kg (29 years) each had no evidence of PS and one autopsy revealed normal number of SN neurons. These observations indicate that LD is not toxic to human SN and are consistent with salutary effect of the drug on the SN in Parkinson's disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1353-8020
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-100
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed-meshheading:11489674-Adolescent, pubmed-meshheading:11489674-Adult, pubmed-meshheading:11489674-Aged, pubmed-meshheading:11489674-Aged, 80 and over, pubmed-meshheading:11489674-Antiparkinson Agents, pubmed-meshheading:11489674-Cadaver, pubmed-meshheading:11489674-Child, pubmed-meshheading:11489674-Disease Progression, pubmed-meshheading:11489674-Dystonia, pubmed-meshheading:11489674-Female, pubmed-meshheading:11489674-Humans, pubmed-meshheading:11489674-Levodopa, pubmed-meshheading:11489674-Longevity, pubmed-meshheading:11489674-Male, pubmed-meshheading:11489674-Middle Aged, pubmed-meshheading:11489674-Parkinsonian Disorders, pubmed-meshheading:11489674-Retrospective Studies, pubmed-meshheading:11489674-Substantia Nigra, pubmed-meshheading:11489674-Survival Analysis, pubmed-meshheading:11489674-Tremor
pubmed:year
2001
pubmed:articleTitle
Levodopa prolongs life expectancy and is non-toxic to substantia nigra.
pubmed:affiliation
Neurology Division, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK, Canada S7N 0W8. rajputa@sdh.sk.ca
pubmed:publicationType
Journal Article