|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0013227,
umls-concept:C0078257,
umls-concept:C0086418,
umls-concept:C0205216,
umls-concept:C0205345,
umls-concept:C0205396,
umls-concept:C0431085,
umls-concept:C0522501,
umls-concept:C0591833,
umls-concept:C0672663,
umls-concept:C0871161,
umls-concept:C1515655,
umls-concept:C1533691
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|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2001-8-7
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|
pubmed:abstractText |
Vinflunine (VFL) is a novel Vinca alkaloid with markedly superior experimental in vivo antitumour activity to its parent molecule, vinorelbine (Navelbine, NVB), against a panel of murine and human tumours. The aim of this study was to establish whether there are differences in the rate and extent of development of resistance, both in vivo and in vitro, to these two newer Vinca alkaloids under identical selection conditions.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0344-5704
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:volume |
48
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
62-70
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|
pubmed:dateRevised |
2003-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:11488526-Animals,
pubmed-meshheading:11488526-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:11488526-Drug Resistance, Multiple,
pubmed-meshheading:11488526-Drug Resistance, Neoplasm,
pubmed-meshheading:11488526-Female,
pubmed-meshheading:11488526-Leukemia P388,
pubmed-meshheading:11488526-Mice,
pubmed-meshheading:11488526-Mice, Inbred DBA,
pubmed-meshheading:11488526-Tubulin,
pubmed-meshheading:11488526-Tumor Cells, Cultured,
pubmed-meshheading:11488526-Vinblastine
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
Markedly diminished drug resistance-inducing properties of vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine) relative to vinorelbine, identified in murine and human tumour cells in vivo and in vitro.
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|
pubmed:affiliation |
Division de Cancérologie Expérimentale I, Centre de Recherche Pierre Fabre, Castres, France. chantal.etievant@pierre-fabre.com
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pubmed:publicationType |
Journal Article
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