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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-8-7
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pubmed:abstractText |
Discodermolide, a natural product from the marine sponge Discodermia dissoluta, has been previously described as an antimitotic agent with microtubule hyperstabilizing properties similar to those of paclitaxel (Taxol). The clinical success of paclitaxel has led to a growing interest in novel antimitotic compounds and the elucidation of their structure-activity characteristics. Analogs of discodermolide were prepared by acetylation of the hydroxyl groups at carbons 3, 7, 11 and/or 17 and tested for biological activity in human tumor cells to determine the structural requirements for tubulin interaction and cytotoxic effects.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0344-5704
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-36
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11488521-Acetylation,
pubmed-meshheading:11488521-Alkanes,
pubmed-meshheading:11488521-Animals,
pubmed-meshheading:11488521-Antineoplastic Agents,
pubmed-meshheading:11488521-Carbamates,
pubmed-meshheading:11488521-Cattle,
pubmed-meshheading:11488521-Lactones,
pubmed-meshheading:11488521-Microtubules,
pubmed-meshheading:11488521-Pyrones,
pubmed-meshheading:11488521-Structure-Activity Relationship,
pubmed-meshheading:11488521-Tubulin
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pubmed:year |
2001
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pubmed:articleTitle |
Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity.
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pubmed:affiliation |
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Fort Pierce, FL 34946, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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