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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-8-6
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pubmed:abstractText |
alpha4 integrins are important mediators of leukocyte migration across vascular endothelium. This pilot placebo-controlled study aimed to assess the safety and efficacy of natalizumab, a recombinant humanized monoclonal antibody to alpha4 integrin, in patients with mild to moderately active Crohn's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0016-5085
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pubmed:author |
pubmed-author:AllisonM CMC,
pubmed-author:AmlotP LPL,
pubmed-author:DonoghueSS,
pubmed-author:FouweatherM GMG,
pubmed-author:GordonF HFH,
pubmed-author:GreenleesCC,
pubmed-author:HamiltonM IMI,
pubmed-author:LaiC WCW,
pubmed-author:PounderR ERE,
pubmed-author:SrivastavaE DED,
pubmed-author:SubhaniJJ
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pubmed:issnType |
Print
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
268-74
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11487536-Adult,
pubmed-meshheading:11487536-Antibodies, Monoclonal,
pubmed-meshheading:11487536-Antigens, CD,
pubmed-meshheading:11487536-Biological Markers,
pubmed-meshheading:11487536-Crohn Disease,
pubmed-meshheading:11487536-Double-Blind Method,
pubmed-meshheading:11487536-Female,
pubmed-meshheading:11487536-Humans,
pubmed-meshheading:11487536-Integrin alpha4,
pubmed-meshheading:11487536-Male,
pubmed-meshheading:11487536-Middle Aged,
pubmed-meshheading:11487536-Quality of Life,
pubmed-meshheading:11487536-Treatment Outcome
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pubmed:year |
2001
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pubmed:articleTitle |
A randomized placebo-controlled trial of a humanized monoclonal antibody to alpha4 integrin in active Crohn's disease.
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pubmed:affiliation |
Centre for Gastroenterology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, England. fionagordon@ownhomeline.freeserve.co.uk
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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