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pubmed-article:11487275pubmed:abstractText2-18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade III invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient.lld:pubmed
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pubmed-article:11487275pubmed:copyrightInfoCopyright 2001 Cancer Research Campaign.lld:pubmed
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pubmed-article:11487275pubmed:articleTitleCGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation.lld:pubmed
pubmed-article:11487275pubmed:affiliationThe Ludwig Institute for Cancer Research/UCL Breast Molecular Pathology Group, Royal Free & University College Medical School, UK.lld:pubmed
pubmed-article:11487275pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11487275pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:11487275pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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