rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
2001-8-6
|
pubmed:abstractText |
The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0340-6245
|
pubmed:author |
pubmed-author:AsazumaNN,
pubmed-author:AtkinsonBB,
pubmed-author:BerlangaOO,
pubmed-author:BethWW,
pubmed-author:BoazDD,
pubmed-author:FramptonJJ,
pubmed-author:JarvisGG,
pubmed-author:MarshallSS,
pubmed-author:SnellDD,
pubmed-author:StaffordMM,
pubmed-author:TulasneDD,
pubmed-author:WatsonS PSP,
pubmed-author:WildeJJ,
pubmed-author:WonerowPP
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pubmed:issnType |
Print
|
pubmed:volume |
86
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
276-88
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:11487016-Amino Acid Motifs,
pubmed-meshheading:11487016-Animals,
pubmed-meshheading:11487016-Collagen,
pubmed-meshheading:11487016-Humans,
pubmed-meshheading:11487016-Platelet Activation,
pubmed-meshheading:11487016-Platelet Membrane Glycoproteins,
pubmed-meshheading:11487016-Protein Structure, Tertiary,
pubmed-meshheading:11487016-Receptors, Immunologic,
pubmed-meshheading:11487016-Signal Transduction,
pubmed-meshheading:11487016-Tyrosine
|
pubmed:year |
2001
|
pubmed:articleTitle |
The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen.
|
pubmed:affiliation |
Department of Pharmacology, University of Oxford, UK. steve.watson@pharm.ox.ac.uk
|
pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|