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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1975-11-6
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pubmed:abstractText |
1. The rabbit aortic strip, guinea-pig ileum and rabbit skeletal muscle sarcoplasmic reticulum preparations were used to determine at which sites and in what manner 8-(N,N-diethylamino)-octyl 3,4,5,-trimethoxybenzoate (TMB-8) interferes with Ca2+ availability in smooth and skeletal muscles. 2. TMB-8 (50 muM) significantly inhibited equivalent responses of the rabbit aortic strip to KCl and noradrenaline. 3. TMB-8 (65 muM) produced no significant alteration in the extracellular space of the guinea-pig ileum as measured with [3H]-sorbitol. 4. The resting cellular Ca2+ influx as well as the resting 45Ca2+ efflux in the guinea-pig ileum preparation were significantly inhibited by TMB-8 (65 muM). 5. TMB-8 (5 muM and 50 muM) had no significant effect on the uptake of 45Ca2+ by the sarcoplasmic reticulum preparation of skeletal muscle; however, TMB-8 (5 muM) did significantly inhibit the caffeine (20 mM)-induced release of 45Ca2+ from this preparation. 6. It is concluded that TMB-8 reduces Ca2+ availability in smooth and skeletal muscles by stabilizing Ca2+ binding to cellular Ca2+ stores and thereby inhibits the release of this Ca2+ by contractile stimuli.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-14079672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-4144684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-4263703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-4264855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-4369004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-4371232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-4539784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-4730519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-4748779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-4894870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-4935801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-4966915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-5012786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-5133603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-5301350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-5330739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-5355574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1148488-5688082
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
279-85
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1148488-Animals,
pubmed-meshheading:1148488-Aorta, Thoracic,
pubmed-meshheading:1148488-Calcium,
pubmed-meshheading:1148488-Calcium Radioisotopes,
pubmed-meshheading:1148488-Diethylamines,
pubmed-meshheading:1148488-Female,
pubmed-meshheading:1148488-Gallic Acid,
pubmed-meshheading:1148488-Guinea Pigs,
pubmed-meshheading:1148488-Ileum,
pubmed-meshheading:1148488-Male,
pubmed-meshheading:1148488-Muscle, Smooth,
pubmed-meshheading:1148488-Muscles,
pubmed-meshheading:1148488-Rabbits,
pubmed-meshheading:1148488-Sarcoplasmic Reticulum,
pubmed-meshheading:1148488-Time Factors
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pubmed:year |
1975
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pubmed:articleTitle |
Studies on the mechanism of action of a new Ca-2+ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride in smooth and skeletal muscles.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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