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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2001-8-2
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pubmed:abstractText |
Transforming growth factor-beta (TGF-beta) is a multifunctional growth factor that has a principal role in growth control through both its cytostatic effect on many different epithelial cell types and its ability to induce programmed cell death in a variety of other cell types. Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the type II TGF-beta receptor to isolate the gene encoding Daxx - a protein associated with the Fas receptor that mediates activation of Jun amino-terminal kinase (JNK) and programmed cell death induced by Fas. The carboxy-terminal portion of Daxx functions as a dominant-negative inhibitor of TGF-beta-induced apoptosis in B-cell lymphomas, and antisense oligonucleotides to Daxx inhibit TGF-beta-induced apoptosis in mouse hepatocytes. Furthermore, Daxx is involved in mediating JNK activation by TGF-beta. Our findings associate Daxx directly with the TGF-beta apoptotic-signalling pathway, and make a biochemical connection between the receptors for TGF-beta and the apoptotic machinery.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DAXX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Daxx protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/transforming growth factor-beta...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1465-7392
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
708-14
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11483955-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11483955-Animals,
pubmed-meshheading:11483955-Antigens, CD95,
pubmed-meshheading:11483955-Apoptosis,
pubmed-meshheading:11483955-COS Cells,
pubmed-meshheading:11483955-Carrier Proteins,
pubmed-meshheading:11483955-Cell Compartmentation,
pubmed-meshheading:11483955-Cell Division,
pubmed-meshheading:11483955-Hepatocytes,
pubmed-meshheading:11483955-Humans,
pubmed-meshheading:11483955-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:11483955-Lymphoma, B-Cell,
pubmed-meshheading:11483955-Mitogen-Activated Protein Kinase 8,
pubmed-meshheading:11483955-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11483955-Nuclear Proteins,
pubmed-meshheading:11483955-Oligonucleotides, Antisense,
pubmed-meshheading:11483955-Protein Structure, Tertiary,
pubmed-meshheading:11483955-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11483955-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:11483955-Signal Transduction,
pubmed-meshheading:11483955-Transforming Growth Factor beta,
pubmed-meshheading:11483955-Tumor Cells, Cultured,
pubmed-meshheading:11483955-Two-Hybrid System Techniques,
pubmed-meshheading:11483955-Yeasts
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pubmed:year |
2001
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pubmed:articleTitle |
TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.
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pubmed:affiliation |
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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