Source:http://linkedlifedata.com/resource/pubmed/id/11483644
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2001-8-2
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| pubmed:abstractText |
Adult rats were subjected to a moderate lateral fluid percussion injury (FPI), followed by survival periods of 2 and 12 h. Regional NMDA subtype glutamate, muscarinic acetylcholine and GABA(A) receptor binding in various brain regions was analysed by quantitative in vitro autoradiography and short-lived positron emission tomography tracers [11C]cyano-dizocilpine, 4-N-[11C]methylpiperidylbenzilate (4-N-[11C]MPB), and [11C]flumazenil, respectively. The binding potential (BP, Bmax/KD) was calculated. The data with [11C]cyano-dizocilpine showed a significant decrease in BP bilaterally for the frontoparietal cortex and hippocampus at both time points, in comparison with that of the sham-operated controls. At 12 h the decrease was significantly more prominent for the ipsilateral cortex and hippocampus than for the contralateral side. The BP of 4-N-[11C]MPB was significantly decreased after 2 h for the trauma-side hippocampus, and after 12 h it had decreased for the trauma-site cortex and the bilateral hippocampus. The [11C]flumazenil exhibited a significant decrease in BP for the trauma-site cortex and the underlying hippocampus by 2 h after the traumatic brain injury. After 12 h a significantly decreased BP was observed only for the trauma-site cortex. The finding of a decreased BP demonstrates the involvement of these receptor systems in the development of cellular dysfunction, which is widespread and not limited to the site of lateral FPI.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Flumazenil,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Muscarinic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/methylpiperidylbenzilate
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0022-3042
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
78
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
417-23
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11483644-Animals,
pubmed-meshheading:11483644-Autoradiography,
pubmed-meshheading:11483644-Binding Sites,
pubmed-meshheading:11483644-Brain,
pubmed-meshheading:11483644-Brain Injuries,
pubmed-meshheading:11483644-Cerebral Cortex,
pubmed-meshheading:11483644-Dizocilpine Maleate,
pubmed-meshheading:11483644-Flumazenil,
pubmed-meshheading:11483644-Frozen Sections,
pubmed-meshheading:11483644-Hippocampus,
pubmed-meshheading:11483644-Humans,
pubmed-meshheading:11483644-Kinetics,
pubmed-meshheading:11483644-Male,
pubmed-meshheading:11483644-Nitriles,
pubmed-meshheading:11483644-Piperidines,
pubmed-meshheading:11483644-Rats,
pubmed-meshheading:11483644-Rats, Sprague-Dawley,
pubmed-meshheading:11483644-Receptors, GABA-A,
pubmed-meshheading:11483644-Receptors, Muscarinic,
pubmed-meshheading:11483644-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:11483644-Tomography, Emission-Computed
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| pubmed:year |
2001
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| pubmed:articleTitle |
Changes in mACh, NMDA and GABA(A) receptor binding after lateral fluid-percussion injury: in vitro autoradiography of rat brain frozen sections.
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| pubmed:affiliation |
Department of Neuroscience, Unit of Pharmacology, Faculty of Medicine, University of Uppsala, Uppsala, Sweden.
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| pubmed:publicationType |
Journal Article
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