Linked Life Data

1148204

Source:http://linkedlifedata.com/resource/pubmed/id/1148204

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
1975-10-30
pubmed:abstractText
Both stereoisomers of 24-hydroxyvitamin D3, i.e. 24(S)-hydroxyvitamin D3 and 24(R)-hydroxyvitamin D3, stimulate intestinal calcium transport almost equally well in the rat. The duration of effect is somewhat shorter for the 24(S)-hydroxyvitamin D3 than for the 24(R)-hydroxyvitamin D3. However, the 24(S)-hydroxyvitamin D3 has little or no activity in the mobilization of calcium from bone, in the growth of rats on a low calcium diet, in the elevation of serum phosphorus of rachitic rats, or in the calcification of bone. On the other hand, the 24(R)-hydroxyvitamin D3 is almost as active as 25-hydroxyvitamin D3 in all of these systems, although its activity is not always of equal duration to that of 25-hydroxyvitamin D3. The selectivity of these systems for only one of the 24-hydroxy stereoisomers supports the idea that in vivo 24-hydroxylation of vitamin D compounds is of functional importance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-2960
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3293-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Importance of the stereochemical position of the 24-hydroxyl to biological activity of 24-hydroxyvitamin D3.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.