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pubmed-article:1148096pubmed:abstractTextCompounds with local anaesthetic properties may be classified according to their action upon the nerve membrane. Four classes of agent are recognized: A. Compounds acting at the exterior of the sodium channels; B. Compounds acting at the axoplasmic part of the sodium channels; C. Compounds acting through a physicochemical mechanism; BC. Compounds acting by a combination of B and C mechanisms. The chemical basis for these different mechanisms is discussed.lld:pubmed
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pubmed-article:1148096pubmed:articleTitleThe chemistry of local anaesthetic agents: classification of blocking agents.lld:pubmed
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