rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1975-11-6
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pubmed:abstractText |
Compounds with local anaesthetic properties may be classified according to their action upon the nerve membrane. Four classes of agent are recognized: A. Compounds acting at the exterior of the sodium channels; B. Compounds acting at the axoplasmic part of the sodium channels; C. Compounds acting through a physicochemical mechanism; BC. Compounds acting by a combination of B and C mechanisms. The chemical basis for these different mechanisms is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Benzocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Benzyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Lidocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenobarbital,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/Saxitoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/Succinimides,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-0912
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47 suppl
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
183-90
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading |
pubmed-meshheading:1148096-Anesthetics, Local,
pubmed-meshheading:1148096-Benzocaine,
pubmed-meshheading:1148096-Benzyl Compounds,
pubmed-meshheading:1148096-Binding, Competitive,
pubmed-meshheading:1148096-Binding Sites,
pubmed-meshheading:1148096-Cell Membrane,
pubmed-meshheading:1148096-Lidocaine,
pubmed-meshheading:1148096-Models, Molecular,
pubmed-meshheading:1148096-Neural Conduction,
pubmed-meshheading:1148096-Neurilemma,
pubmed-meshheading:1148096-Phenobarbital,
pubmed-meshheading:1148096-Phenols,
pubmed-meshheading:1148096-Saxitoxin,
pubmed-meshheading:1148096-Sodium,
pubmed-meshheading:1148096-Structure-Activity Relationship,
pubmed-meshheading:1148096-Succinimides,
pubmed-meshheading:1148096-Tetrodotoxin
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pubmed:year |
1975
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pubmed:articleTitle |
The chemistry of local anaesthetic agents: classification of blocking agents.
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pubmed:publicationType |
Journal Article
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