Linked Life Data

11480708

Source:http://linkedlifedata.com/resource/pubmed/id/11480708

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-8-1
pubmed:abstractText
OBJECTIVE: To reach consensus on the application of quantitative cytochemical analysis of chromosomal and DNA aneuploidy in cervical cytopathology. CONCLUSION: The current Pap test has limited specificity to predict cancer and its truly progressive pre-malignant lesions. Infection with human papillomavirus may trigger genetic instability, hyperproliferation and immortalization of the cervical mucosa and cause cervical cancer. Several related molecular markers have been shown to be informative about this neoplastic process. Quantitative analysis of chromosomal and DNA aneuploidy has been shown to be an important tool for identifying (progression to) high grade squamous intraepithelial lesions. A high degree of standardization (material handling, calibration and quality control, measurement and interpretation of results) is required for accurate and reproducible measurements. Areas for further study are presented.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5547
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
499-501
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Summary statement on quantitative cytochemistry (DNA and molecular biology): Task Force 8.
pubmed:affiliation
University Hospital Nijmegen, Nijmegen, the Netherlands. t.hanselaar@pathol.azn.nl
pubmed:publicationType
Journal Article, Review, Consensus Development Conference