Source:http://linkedlifedata.com/resource/pubmed/id/11479624
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2001-7-31
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pubmed:abstractText |
Integase interactor 1 (INI1), also known as hSNF5, is a protein that interacts with HIV-1 integrase. We report here that a cytoplasmically localized fragment of INI1 (S6; aa183-294) containing the minimal integrase-interaction domain potently inhibits HIV-1 particle production and replication. Mutations in S6 or integrase that disrupt integrase-INI1 interaction abrogated the inhibitory effect. An integrase-deficient HIV-1 transcomplemented with integrase fused to Vpr was not affected by S6. INI1 was specifically incorporated into virions and was required for efficient HIV-1 particle production. These results indicate that INI1 is required for late events in the viral life cycle, and that ectopic expression of S6 inhibits HIV-1 replication in a transdominant manner via its specific interaction with integrase within the context of Gag-Pol, providing a novel strategy to control HIV-1 replication.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1078-8956
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
920-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11479624-Base Sequence,
pubmed-meshheading:11479624-Cell Line,
pubmed-meshheading:11479624-Cell Nucleus,
pubmed-meshheading:11479624-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:11479624-Cytoplasm,
pubmed-meshheading:11479624-DNA Primers,
pubmed-meshheading:11479624-DNA-Binding Proteins,
pubmed-meshheading:11479624-Genes, Dominant,
pubmed-meshheading:11479624-HIV-1,
pubmed-meshheading:11479624-Humans,
pubmed-meshheading:11479624-Transcription Factors,
pubmed-meshheading:11479624-Virion
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pubmed:year |
2001
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pubmed:articleTitle |
Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1.
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pubmed:affiliation |
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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