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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-7-31
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pubmed:abstractText |
The bioactive peptide endothelin-1 is elevated during and after cardiopulmonary bypass and exerts cardiovascular effects through its 2 receptor subtypes, endothelin-1A and endothelin-1B. Increased endothelin-1A receptor stimulation after cardiopulmonary bypass can cause increased pulmonary vascular resistance and modulate myocardial contractility. However, whether and to what degree selective endothelin-1A blockade influences these parameters in the postbypass setting is not completely understood.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-5223
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
365-70
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pubmed:dateRevised |
2008-6-5
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pubmed:meshHeading |
pubmed-meshheading:11479511-Analysis of Variance,
pubmed-meshheading:11479511-Animals,
pubmed-meshheading:11479511-Cardiopulmonary Bypass,
pubmed-meshheading:11479511-Disease Models, Animal,
pubmed-meshheading:11479511-Endothelin-1,
pubmed-meshheading:11479511-Hemodynamics,
pubmed-meshheading:11479511-Hypertension, Pulmonary,
pubmed-meshheading:11479511-Isoxazoles,
pubmed-meshheading:11479511-Pulmonary Circulation,
pubmed-meshheading:11479511-Receptors, Endothelin,
pubmed-meshheading:11479511-Swine,
pubmed-meshheading:11479511-Thiophenes,
pubmed-meshheading:11479511-Vascular Resistance,
pubmed-meshheading:11479511-Ventricular Function, Left
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pubmed:year |
2001
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pubmed:articleTitle |
Endothelin receptor subtype A blockade selectively reduces pulmonary pressure after cardiopulmonary bypass.
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pubmed:affiliation |
Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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