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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-7-31
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pubmed:abstractText |
Therapeutic angiogenesis by the administration of recombinant vascular endothelial growth factor (rVEGF) is a novel strategy for the treatment of ischemic disorders. rVEGF has been delivered as a protein, by plasmid DNA, and by genetically engineered cells with different pharmacokinetic and physiological properties. In the present study, we examined a new method for delivery of rVEGF using implantable bioartificial muscle (BAM) tissues made from genetically modified primary skeletal myoblasts. Our goal was to determine whether the rVEGF delivered by this technique promoted controlled angiogenesis in nonischemic and/or ischemic adult mouse tissue.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
31
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
594-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11479259-Animals,
pubmed-meshheading:11479259-Antigens, CD31,
pubmed-meshheading:11479259-Cell Division,
pubmed-meshheading:11479259-Cell Line,
pubmed-meshheading:11479259-Cells, Cultured,
pubmed-meshheading:11479259-Endothelial Growth Factors,
pubmed-meshheading:11479259-Endothelium, Vascular,
pubmed-meshheading:11479259-Gene Transfer Techniques,
pubmed-meshheading:11479259-Graft Survival,
pubmed-meshheading:11479259-Humans,
pubmed-meshheading:11479259-Immunohistochemistry,
pubmed-meshheading:11479259-Ischemia,
pubmed-meshheading:11479259-Lymphokines,
pubmed-meshheading:11479259-Male,
pubmed-meshheading:11479259-Mice,
pubmed-meshheading:11479259-Mice, Inbred C3H,
pubmed-meshheading:11479259-Muscle, Skeletal,
pubmed-meshheading:11479259-Neovascularization, Physiologic,
pubmed-meshheading:11479259-Recombinant Proteins,
pubmed-meshheading:11479259-Time Factors,
pubmed-meshheading:11479259-Vascular Endothelial Growth Factor A,
pubmed-meshheading:11479259-Vascular Endothelial Growth Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Recombinant vascular endothelial growth factor secreted from tissue-engineered bioartificial muscles promotes localized angiogenesis.
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pubmed:affiliation |
Department of Pathology, Brown University School of Medicine, and The Miriam Hospital, Providence, RI, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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