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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2001-7-31
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pubmed:abstractText |
cAMP response element binding protein-2 (CREB-2) is a basic leucine zipper (bZIP) factor that was originally described as a repressor of CRE-dependent transcription but that can also act as a transcriptional activator. Moreover, CREB-2 is able to function in association with the viral Tax protein as an activator of the human T-cell leukemia virus type I (HTLV-I) promoter. Here we show that CREB-2 is able to interact with C/EBP-homologous protein (CHOP), a bZIP transcription factor known to inhibit CAAT/enhancer-dependent transcription. Cotransfection of CHOP with CREB-2 results in decreased activation driven by the cellular CRE motif or the HTLV-I proximal Tax-responsive element, confirming that CREB-2 and CHOP can interact with each other in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATF4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Activating Transcription Factor 4,
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DDIT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor CHOP,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
502
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-62
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11478948-Activating Transcription Factor 4,
pubmed-meshheading:11478948-Animals,
pubmed-meshheading:11478948-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:11478948-COS Cells,
pubmed-meshheading:11478948-Cell Line,
pubmed-meshheading:11478948-Cell Nucleus,
pubmed-meshheading:11478948-Cercopithecus aethiops,
pubmed-meshheading:11478948-Gene Expression Regulation, Viral,
pubmed-meshheading:11478948-Gene Products, tat,
pubmed-meshheading:11478948-HIV-1,
pubmed-meshheading:11478948-Human T-lymphotropic virus 1,
pubmed-meshheading:11478948-Humans,
pubmed-meshheading:11478948-Leucine Zippers,
pubmed-meshheading:11478948-Promoter Regions, Genetic,
pubmed-meshheading:11478948-Recombinant Fusion Proteins,
pubmed-meshheading:11478948-Saccharomyces cerevisiae,
pubmed-meshheading:11478948-Transcription, Genetic,
pubmed-meshheading:11478948-Transcription Factor CHOP,
pubmed-meshheading:11478948-Transcription Factors,
pubmed-meshheading:11478948-Two-Hybrid System Techniques,
pubmed-meshheading:11478948-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2001
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pubmed:articleTitle |
The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP).
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pubmed:affiliation |
Laboratoire Infections Rétrovirales et Signalisation Cellulaire, CNRS EP 2104/Université Montpellier I, Institut de Biologie, 4 Bd Henri IV, 34060 Montpellier, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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