Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-7-27
pubmed:abstractText
The proinflammatory cytokine interferon (IFN)-gamma has been shown to influence the course of multiple sclerosis (MS). The IFN-gamma (IFNG) contains a multiallelic dinucleotide repeat in intron 1. To investigate whether alleles at this locus influence susceptibility to MS, we performed linkage and familial association analyses on 100 sibling pairs from four Nordic countries, and case-control association analysis on 220 intermediately disabled sporadic MS patients and 266 controls. To determine the effect of the polymorphism on disease outcome, we compared genotype frequencies in the most and least disabled octiles of a total cohort of 913 cases. We also measured IFN-gamma mRNA levels in unstimulated peripheral blood mononuclear cells from 46 MS patients and 27 controls grouped according to IFNG intron 1 genotype. Both nonparametric linkage analysis and transmission disequilibrium testing of the 100 sibling pairs produced negative results. Genotype frequencies for intermediate-MS patients did not differ significantly from those for controls; nor did genotype frequencies in the benign-MS octile differ significantly from those in the severe-MS octle. Comparison of IFN-gamma mRNA levels in genotype-conditioned subgroups revealed no significant differences. Thus, alleles at the IFNG intron 1 dinucleotide repeat appear to affect neither MS susceptibility and severity nor IFN-gamma mRNA expression in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1352-4585
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-63
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11475438-Case-Control Studies, pubmed-meshheading:11475438-Cohort Studies, pubmed-meshheading:11475438-Dinucleotide Repeats, pubmed-meshheading:11475438-Disability Evaluation, pubmed-meshheading:11475438-Family Health, pubmed-meshheading:11475438-Female, pubmed-meshheading:11475438-Finland, pubmed-meshheading:11475438-Gene Expression, pubmed-meshheading:11475438-Genetic Linkage, pubmed-meshheading:11475438-Genotype, pubmed-meshheading:11475438-Humans, pubmed-meshheading:11475438-Interferon-gamma, pubmed-meshheading:11475438-Introns, pubmed-meshheading:11475438-Male, pubmed-meshheading:11475438-Multiple Sclerosis, pubmed-meshheading:11475438-Nuclear Family, pubmed-meshheading:11475438-Polymorphism, Genetic, pubmed-meshheading:11475438-Prognosis, pubmed-meshheading:11475438-RNA, Messenger, pubmed-meshheading:11475438-Scandinavia, pubmed-meshheading:11475438-Severity of Illness Index
pubmed:year
2001
pubmed:articleTitle
Analysis of an interferon-gamma gene dinucleotide-repeat polymorphism in Nordic multiple sclerosis patients.
pubmed:affiliation
Division of Neurology, NEUROTEC, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't