|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2001-7-27
|
|
pubmed:abstractText |
The small GTPase Rac1 is a key signaling protein that mediates a number of important physiologic functions including the organization of the actin cytoskeleton, lipid metabolism, and gene transcription. Rac1 has also been implicated in oncogenic transformation. Expression of constitutively active Rac1 in Rat1 fibroblasts elicits serum- and anchorage-independent growth and causes tumorigenicity in nude mice. The signaling pathways that mediate the role of Rac in cell transformation remain to be identified. Here, we study the role of Rac in cell survival in the absence of serum.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1076-1551
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
293-300
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:11474575-Animals,
pubmed-meshheading:11474575-Apoptosis,
pubmed-meshheading:11474575-Cell Division,
pubmed-meshheading:11474575-Cell Survival,
pubmed-meshheading:11474575-Cells, Cultured,
pubmed-meshheading:11474575-Culture Media, Serum-Free,
pubmed-meshheading:11474575-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:11474575-Fibroblasts,
pubmed-meshheading:11474575-GTPase-Activating Proteins,
pubmed-meshheading:11474575-Genes, Reporter,
pubmed-meshheading:11474575-Immune Sera,
pubmed-meshheading:11474575-In Situ Nick-End Labeling,
pubmed-meshheading:11474575-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:11474575-MAP Kinase Kinase 4,
pubmed-meshheading:11474575-Microscopy, Video,
pubmed-meshheading:11474575-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:11474575-Mutation,
pubmed-meshheading:11474575-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:11474575-Phosphorylation,
pubmed-meshheading:11474575-Protein Binding,
pubmed-meshheading:11474575-Rats,
pubmed-meshheading:11474575-Signal Transduction,
pubmed-meshheading:11474575-rac1 GTP-Binding Protein
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts.
|
|
pubmed:affiliation |
Onyx Pharmaceuticals, Richmond, CA, USA. mruggieri@picower.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
