Linked Life Data

11473832

Source:http://linkedlifedata.com/resource/pubmed/id/11473832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2001-7-27
pubmed:abstractText
The liver is known for its ability to induce antigen (Ag)-specific immune tolerance. Among the different cell populations involved in the induction of hepatic tolerance, the liver sinusoidal endothelial cells (LSECs) are particularly important because they are highly efficient at presenting soluble Ags to CD4(+) and CD8(+) T cells. The crosspresentation of soluble Ags to CD8(+) T cells was believed previously to be restricted to professional Ag-presenting cells (APCs) such as dendritic cells (DCs). However, in contrast to DCs, crosspresentation by LSECs can induce Ag-specific immune tolerance. It is proposed that these organ-resident APCs act as sessile hepatic APCs that control the immune responses to soluble blood-borne Ags, in concert with APCs in lymphatic tissue.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1471-4906
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
432-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells.
pubmed:affiliation
Zentrum für Molekulare Biologie Heidelberg (ZMBH), Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany. P.Knolle@ZMBH.Uni-Heidelburg.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't