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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-7-27
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pubmed:abstractText |
In vitro cytotoxic activities of 24 quaternary protoberberine alkaloids related to berberine have been evaluated using a human cancer cell line panel coupled with a drug sensitivity database. Extending the alkyl chain at position 8 or 13 strongly influenced the cytotoxic activity, that is, relative lipophilicity as well as the size of the substituent affects cytotoxicity. The highest level of activity was observed in 8- or 13-hexyl-substituted derivatives of berberine. Structure-activity relationships are described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
896-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11473418-Animals,
pubmed-meshheading:11473418-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:11473418-Berberine,
pubmed-meshheading:11473418-Berberine Alkaloids,
pubmed-meshheading:11473418-Brain Neoplasms,
pubmed-meshheading:11473418-Breast Neoplasms,
pubmed-meshheading:11473418-Colonic Neoplasms,
pubmed-meshheading:11473418-Crystallography, X-Ray,
pubmed-meshheading:11473418-Databases, Factual,
pubmed-meshheading:11473418-Doxorubicin,
pubmed-meshheading:11473418-Female,
pubmed-meshheading:11473418-Humans,
pubmed-meshheading:11473418-Lung Neoplasms,
pubmed-meshheading:11473418-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11473418-Mice,
pubmed-meshheading:11473418-Mitomycin,
pubmed-meshheading:11473418-Molecular Structure,
pubmed-meshheading:11473418-Ovarian Neoplasms,
pubmed-meshheading:11473418-Papaver,
pubmed-meshheading:11473418-Plants, Medicinal,
pubmed-meshheading:11473418-Stomach Neoplasms,
pubmed-meshheading:11473418-Structure-Activity Relationship,
pubmed-meshheading:11473418-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
In vitro cytotoxicity of the protoberberine-type alkaloids.
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pubmed:affiliation |
Kobe Pharmaceutical University, 4-19-1 Motoyamakita, Higashinada-ku, Kobe 658-8558, Japan. K-iwasa@kobepharma-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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