Linked Life Data

11473047

Source:http://linkedlifedata.com/resource/pubmed/id/11473047

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2001-7-26
pubmed:abstractText
Insulin sensitivity (euglycemic clamp, insulin infusion rate: 40 mU. m(-2). min(-1)) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m(2). Of those 30 subjects, 9 had pure fatty liver and 21 had evidence of steatohepatitis. In addition, 10 patients with type 2 diabetes under good metabolic control and 10 healthy subjects were studied. Most NAFLD patients had central fat accumulation, increased triglycerides and uric acid, and low HDL cholesterol, irrespective of BMI. Glucose disposal during the clamp was reduced by nearly 50% in NAFLD patients, as well as in patients with normal body weight, to an extent similar to that of the type 2 diabetic patients. Basal free fatty acids were increased, whereas insulin-mediated suppression of lipolysis was less effective (-69% in NAFLD vs. -84% in control subjects; P = 0.003). Postabsorptive hepatic glucose production (HGP), measured by [6,6-(2)H(2)]glucose, was normal. In response to insulin infusion, HGP decreased by only 63% of basal in NAFLD vs. 84% in control subjects (P = 0.002). Compared with type 2 diabetic patients, NAFLD patients were characterized by lower basal HGP, but with similarly reduced insulin-mediated suppression of HGP. There was laboratory evidence of iron overload in many NAFLD patients, but clinical, histological, and biochemical data (including insulin sensitivity) were not correlated with iron status. Four subjects were heterozygous for mutation His63Asp of the HFE gene of familiar hemochromatosis. We concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity. NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1844-50
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11473047-Adult, pubmed-meshheading:11473047-Aged, pubmed-meshheading:11473047-Blood Glucose, pubmed-meshheading:11473047-Body Constitution, pubmed-meshheading:11473047-Cardiovascular Diseases, pubmed-meshheading:11473047-Cholesterol, pubmed-meshheading:11473047-Cholesterol, HDL, pubmed-meshheading:11473047-Diabetes Mellitus, Type 2, pubmed-meshheading:11473047-Fatty Acids, Nonesterified, pubmed-meshheading:11473047-Fatty Liver, pubmed-meshheading:11473047-Female, pubmed-meshheading:11473047-Glucose, pubmed-meshheading:11473047-Glucose Clamp Technique, pubmed-meshheading:11473047-Humans, pubmed-meshheading:11473047-Hyperinsulinism, pubmed-meshheading:11473047-Hypertension, pubmed-meshheading:11473047-Infusions, Intravenous, pubmed-meshheading:11473047-Insulin, pubmed-meshheading:11473047-Insulin Resistance, pubmed-meshheading:11473047-Lipolysis, pubmed-meshheading:11473047-Liver, pubmed-meshheading:11473047-Male, pubmed-meshheading:11473047-Middle Aged, pubmed-meshheading:11473047-Reference Values
pubmed:year
2001
pubmed:articleTitle
Nonalcoholic fatty liver disease: a feature of the metabolic syndrome.
pubmed:affiliation
Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy. marchreg@med.unibo.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't