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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-7-25
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pubmed:databankReference |
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pubmed:abstractText |
Mitochondrial processing peptidase (MPP) is a metalloendopeptidase that cleaves the N-terminal signal sequences of nuclear-encoded proteins targeted for transport from the cytosol to the mitochondria. Mitochondrial signal sequences vary in length and sequence, but each is cleaved at a single specific site by MPP. The cleavage sites typically contain an arginine at position -2 (in the N-terminal portion) from the scissile peptide bond in addition to other distal basic residues, and an aromatic residue at position +1. Mitochondrial import machinery recognizes amphiphilic helical conformations in signal sequences. However, it is unclear how MPP specifically recognizes diverse presequence substrates.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
615-25
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11470436-Amino Acid Sequence,
pubmed-meshheading:11470436-Binding Sites,
pubmed-meshheading:11470436-Crystallography, X-Ray,
pubmed-meshheading:11470436-Electron Transport Complex III,
pubmed-meshheading:11470436-Electron Transport Complex IV,
pubmed-meshheading:11470436-Malate Dehydrogenase,
pubmed-meshheading:11470436-Membrane Proteins,
pubmed-meshheading:11470436-Metalloendopeptidases,
pubmed-meshheading:11470436-Models, Molecular,
pubmed-meshheading:11470436-Molecular Sequence Data,
pubmed-meshheading:11470436-Mutation,
pubmed-meshheading:11470436-Peptides,
pubmed-meshheading:11470436-Protein Conformation,
pubmed-meshheading:11470436-Protein Sorting Signals,
pubmed-meshheading:11470436-Recombinant Proteins,
pubmed-meshheading:11470436-Signal Transduction
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pubmed:year |
2001
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pubmed:articleTitle |
Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.
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pubmed:affiliation |
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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pubmed:publicationType |
Journal Article
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