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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-7-25
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pubmed:abstractText |
The inducible nitric oxide synthase (iNOS) is strongly expressed following inflammatory stimuli. Adenosine 3',5'-cyclic monophosphate (cAMP) increases iNOS expression and activity in a number of cell types but decreases cytokine-stimulated iNOS expression in hepatocytes. The mechanisms for this effect are unknown.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Bromo Cyclic Adenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/9-(tetrahydro-2-furyl)-adenine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Bucladesine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-4804
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
258-64
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11469895-8-Bromo Cyclic Adenosine Monophosphate,
pubmed-meshheading:11469895-Adenine,
pubmed-meshheading:11469895-Adenylate Cyclase,
pubmed-meshheading:11469895-Animals,
pubmed-meshheading:11469895-Bucladesine,
pubmed-meshheading:11469895-Cells, Cultured,
pubmed-meshheading:11469895-Cyclic AMP,
pubmed-meshheading:11469895-Enzyme Inhibitors,
pubmed-meshheading:11469895-Forskolin,
pubmed-meshheading:11469895-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:11469895-Glucagon,
pubmed-meshheading:11469895-Hepatocytes,
pubmed-meshheading:11469895-Interleukin-1,
pubmed-meshheading:11469895-Male,
pubmed-meshheading:11469895-Muscle, Smooth, Vascular,
pubmed-meshheading:11469895-NF-kappa B,
pubmed-meshheading:11469895-Nitric Oxide Synthase,
pubmed-meshheading:11469895-Nitric Oxide Synthase Type II,
pubmed-meshheading:11469895-Promoter Regions, Genetic,
pubmed-meshheading:11469895-Pulmonary Artery,
pubmed-meshheading:11469895-RNA, Messenger,
pubmed-meshheading:11469895-Rats,
pubmed-meshheading:11469895-Rats, Sprague-Dawley,
pubmed-meshheading:11469895-Second Messenger Systems,
pubmed-meshheading:11469895-Sepsis,
pubmed-meshheading:11469895-Transfection
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pubmed:year |
2001
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pubmed:articleTitle |
cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity in cultured rat hepatocytes.
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pubmed:affiliation |
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA. harbrechtbg@msx.upmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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