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pubmed-article:11468200pubmed:abstractTextPlatelet deposition and aggregation are central to the pathogenesis of ischemic complications of acute coronary syndromes (ACS). Pharmacodynamic effects of the platelet glycoprotein IIb/IIIa antagonist eptifibatide have been delineated in healthy subjects but not in patients with ACS. We assessed effects of eptifibatide on ex vivo platelet aggregation in patients enrolled in the Platelet glycoprotein IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin (eptifibatide) Therapy (PURSUIT) trial of ACS.lld:pubmed
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pubmed-article:11468200pubmed:articleTitlePharmacodynamics and pharmacokinetics of eptifibatide in patients with acute coronary syndromes: prospective analysis from PURSUIT.lld:pubmed
pubmed-article:11468200pubmed:affiliationDuke Clinical Research Institute, Durham, NC, USA.lld:pubmed
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