Linked Life Data

11466557

Source:http://linkedlifedata.com/resource/pubmed/id/11466557

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2001-7-23
pubmed:abstractText
The acquired immune system is a complex and very effective defense against invading pathogens such as bacteria and viruses. T cells are central to the acquired immune system by controlling B and T cell activation and induction of T cell effector functions. The key event for T cell activation is the recognition of a specific antigen by the T cell receptor. During the past decade antigen recognition of T cells has been investigated intensively leading to new insights into the molecular mechanisms of T cell activation. In addition to the resolution of the molecular structure of the trimolecular complex (T cell receptor, peptide, major histocompatibility complex) functional studies have demonstrated the flexibility of the T cell receptor interaction with its ligand. These observations have had strong implications for the understanding of T cell selection, maturation, and repertoire maintenance. In addition, the flexibility of the T cell receptor has provided the basis for novel methods to dissect antigen recognition and define the repertoire of ligands for a given receptor. Here, we summarize recent progress on T cell recognition and method innovations with respect to future studies in autoimmune diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0946-2716
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
358-67
pubmed:dateRevised
2011-7-8
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
New approaches to dissect degeneracy and specificity in T cell antigen recognition.
pubmed:affiliation
Clinical Neuroimmunology Group, Department of Neurology, Philipps-University, Rudolf-Bultmann Strasse 8, 35033 Marburg, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't