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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2001-7-23
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pubmed:abstractText |
The pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor (PAC1) is a G-protein-coupled receptor binding the strongly conserved neuropeptide PACAP with 1000-fold higher affinity than the related peptide vasoactive intestinal peptide. PAC1-mediated signaling has been implicated in neuronal differentiation and synaptic plasticity. To gain further insight into the biological significance of PAC1-mediated signaling in vivo, we generated two different mutant mouse strains, harboring either a complete or a forebrain-specific inactivation of PAC1. Mutants from both strains show a deficit in contextual fear conditioning, a hippocampus-dependent associative learning paradigm. In sharp contrast, amygdala-dependent cued fear conditioning remains intact. Interestingly, no deficits in other hippocampus-dependent tasks modeling declarative learning such as the Morris water maze or the social transmission of food preference are observed. At the cellular level, the deficit in hippocampus-dependent associative learning is accompanied by an impairment of mossy fiber long-term potentiation (LTP). Because the hippocampal expression of PAC1 is restricted to mossy fiber terminals, we conclude that presynaptic PAC1-mediated signaling at the mossy fiber synapse is involved in both LTP and hippocampus-dependent associative learning.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1529-2401
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pubmed:author |
pubmed-author:GaryKK,
pubmed-author:GröneH JHJ,
pubmed-author:KellendonkCC,
pubmed-author:KonnerthAA,
pubmed-author:KovalchukYY,
pubmed-author:LippH PHP,
pubmed-author:MaldonadoRR,
pubmed-author:MartinMM,
pubmed-author:OttoCC,
pubmed-author:SchützGG,
pubmed-author:TroncheFF,
pubmed-author:WolferD PDP,
pubmed-author:ZuschratterWW
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5520-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11466423-Animals,
pubmed-meshheading:11466423-Association Learning,
pubmed-meshheading:11466423-Avoidance Learning,
pubmed-meshheading:11466423-Cues,
pubmed-meshheading:11466423-Electroshock,
pubmed-meshheading:11466423-Long-Term Potentiation,
pubmed-meshheading:11466423-Maze Learning,
pubmed-meshheading:11466423-Mice,
pubmed-meshheading:11466423-Mice, Knockout,
pubmed-meshheading:11466423-Mice, Mutant Strains,
pubmed-meshheading:11466423-Mossy Fibers, Hippocampal,
pubmed-meshheading:11466423-Neuronal Plasticity,
pubmed-meshheading:11466423-Patch-Clamp Techniques,
pubmed-meshheading:11466423-Presynaptic Terminals,
pubmed-meshheading:11466423-Prosencephalon,
pubmed-meshheading:11466423-Receptors, Pituitary Adenylate Cyclase-Activating...,
pubmed-meshheading:11466423-Receptors, Pituitary Adenylate Cyclase-Activating...,
pubmed-meshheading:11466423-Receptors, Pituitary Hormone,
pubmed-meshheading:11466423-Signal Transduction,
pubmed-meshheading:11466423-Social Behavior
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pubmed:year |
2001
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pubmed:articleTitle |
Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient mice.
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pubmed:affiliation |
Divisions of Molecular Biology of the Cell and Experimental Pathology, German Cancer Research Center, 69120 Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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