|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2001-7-23
|
|
pubmed:abstractText |
Immunostimulatory DNA sequences (ISS, also known as CpG motifs) are pathogen-associated molecular patterns that are potent stimulators of innate immunity. We tested the ability of ISS to act as an immunostimulatory pathogen-associated molecular pattern in a model HIV vaccine using gp120 envelope protein as the Ag. Mice immunized with gp120 and ISS, or a gp120:ISS conjugate, developed gp120-specific immune responses which included: 1) Ab production; 2) a Th1-biased cytokine response; 3) the secretion of beta-chemokines, which are known to inhibit the use of the CCR5 coreceptor by HIV; 4) CTL activity; 5) mucosal immune responses; and 6) CD8 T cell responses that were independent of CD4 T cell help. Based on these results, ISS-based immunization holds promise for the development of an effective preventive and therapeutic HIV vaccine.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AIDS Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CPG-oligonucleotide,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/H-2K(K) antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, DNA
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
pubmed-author:BelyakovI MIM,
pubmed-author:BerzofskyJ AJA,
pubmed-author:CinmanNN,
pubmed-author:DattaS KSK,
pubmed-author:HayashiTT,
pubmed-author:HornerA AAA,
pubmed-author:NguyenM DMD,
pubmed-author:RaoNN,
pubmed-author:RichmanD DDD,
pubmed-author:TakabayashiKK,
pubmed-author:Van UdenJ HJH
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
167
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1584-91
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:11466380-AIDS Vaccines,
pubmed-meshheading:11466380-Adjuvants, Immunologic,
pubmed-meshheading:11466380-Administration, Intranasal,
pubmed-meshheading:11466380-Animals,
pubmed-meshheading:11466380-Anti-HIV Agents,
pubmed-meshheading:11466380-Chemokines,
pubmed-meshheading:11466380-CpG Islands,
pubmed-meshheading:11466380-Cytokines,
pubmed-meshheading:11466380-Cytotoxicity, Immunologic,
pubmed-meshheading:11466380-Female,
pubmed-meshheading:11466380-H-2 Antigens,
pubmed-meshheading:11466380-HIV Envelope Protein gp120,
pubmed-meshheading:11466380-Immunity, Mucosal,
pubmed-meshheading:11466380-Immunoglobulin A,
pubmed-meshheading:11466380-Immunoglobulin G,
pubmed-meshheading:11466380-Lymphocyte Activation,
pubmed-meshheading:11466380-Mice,
pubmed-meshheading:11466380-Mice, Inbred BALB C,
pubmed-meshheading:11466380-Oligodeoxyribonucleotides,
pubmed-meshheading:11466380-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11466380-Th1 Cells,
pubmed-meshheading:11466380-Vaccines, DNA
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites.
|
|
pubmed:affiliation |
Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
