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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
1979-12-18
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pubmed:abstractText |
A series of 3-quinolinediamines (1g, 2c, and 3e) structurally related to primaquine and 4-methylprimaquine have been prepared and tested for antimalarial activity against Plasmodium berghei in mice and antileishmanial activity against Leishmania donovani in the hamster. All were inactive. In addition, three 5-quinolinediamines (4b, 5, and 6) were prepared. All were inactive against Leishmania donovani in hamsters. One of the examples, 6, was curative against Plasmodium cynmolgi in the rhesus monkey.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-2623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1005-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:114654-Aminoquinolines,
pubmed-meshheading:114654-Animals,
pubmed-meshheading:114654-Antimalarials,
pubmed-meshheading:114654-Chemical Phenomena,
pubmed-meshheading:114654-Chemistry,
pubmed-meshheading:114654-Cricetinae,
pubmed-meshheading:114654-Haplorhini,
pubmed-meshheading:114654-Leishmania,
pubmed-meshheading:114654-Malaria,
pubmed-meshheading:114654-Mice,
pubmed-meshheading:114654-Plasmodium berghei
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pubmed:year |
1979
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pubmed:articleTitle |
Antimalarials. 11. Synthesis of 3- and 5-aminoquinolines as potential antimalarials.
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pubmed:publicationType |
Journal Article
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