|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2001-7-20
|
|
pubmed:abstractText |
We previously concluded that the Kv2.1 K(+) channel inactivates preferentially from partially activated closed states. We report here that the Kv3.1 channel also exhibits two key features of this inactivation mechanism: a U-shaped voltage dependence measured at 10 s and stronger inactivation with repetitive pulses than with a single long depolarization. More surprisingly, slow inactivation of the Kv1 Shaker K(+) channel (Shaker B Delta 6--46) also has a U-shaped voltage dependence for 10-s depolarizations. The time and voltage dependence of recovery from inactivation reveals two distinct components for Shaker. Strong depolarizations favor inactivation that is reduced by K(o)(+) or by partial block by TEA(o), as previously reported for slow inactivation of Shaker. However, depolarizations near 0 mV favor inactivation that recovers rapidly, with strong voltage dependence (as for Kv2.1 and 3.1). The fraction of channels that recover rapidly is increased in TEA(o) or high K(o)(+). We introduce the term U-type inactivation for the mechanism that is dominant in Kv2.1 and Kv3.1. U-type inactivation also makes a major but previously unrecognized contribution to slow inactivation of Shaker.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-10228180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-10352033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-10384687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-10388754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-10435997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-10561420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-10620284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-1378392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-1931050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-2052588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-2122519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-2299331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-2580081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-2784693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-7517034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-7576643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8038375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8038379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8081712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8081714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8161454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8189206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8189208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8437886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8571129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8587608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8608004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8788936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8789096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8799887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8968586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-8994601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-9080366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-9222902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-9222903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-9348329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-9404006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-9545040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-9545046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-9620706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-9649378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-9696692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11463627-9758858
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Voltage-Gated,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Shaker Superfamily of Potassium...,
http://linkedlifedata.com/resource/pubmed/chemical/Shaker protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Shaw Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Tetraethylammonium
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0006-3495
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
81
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
814-26
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:11463627-Allosteric Regulation,
pubmed-meshheading:11463627-Animals,
pubmed-meshheading:11463627-Drosophila Proteins,
pubmed-meshheading:11463627-Drosophila melanogaster,
pubmed-meshheading:11463627-Electrophysiology,
pubmed-meshheading:11463627-Kinetics,
pubmed-meshheading:11463627-Membrane Potentials,
pubmed-meshheading:11463627-Models, Biological,
pubmed-meshheading:11463627-Neuropeptides,
pubmed-meshheading:11463627-Oocytes,
pubmed-meshheading:11463627-Potassium Channel Blockers,
pubmed-meshheading:11463627-Potassium Channels,
pubmed-meshheading:11463627-Potassium Channels, Voltage-Gated,
pubmed-meshheading:11463627-RNA,
pubmed-meshheading:11463627-Shaker Superfamily of Potassium Channels,
pubmed-meshheading:11463627-Shaw Potassium Channels,
pubmed-meshheading:11463627-Tetraethylammonium,
pubmed-meshheading:11463627-Xenopus laevis
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
U-type inactivation of Kv3.1 and Shaker potassium channels.
|
|
pubmed:affiliation |
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
