Source:http://linkedlifedata.com/resource/pubmed/id/11463303
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
15
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| pubmed:dateCreated |
2001-7-20
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| pubmed:abstractText |
[reaction: see text] Novel tripeptide-derived peptidomimetics 1, 7ab, and 8ab, inspired by templates generated by the structure-generating program GrowMol, were synthesized, shown to inhibit Rhizopus chinensis pepsin, and found by X-ray crystallography to bind to the enzyme in the GrowMol-predicted mode. Repetitive evaluation of the computer-generated templates for synthetic feasibility and optimal enzyme interactions led to the designed compounds.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
1523-7060
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
26
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2309-12
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:11463303-Aspartic Acid Endopeptidases,
pubmed-meshheading:11463303-Computer Simulation,
pubmed-meshheading:11463303-Crystallography, X-Ray,
pubmed-meshheading:11463303-Drug Design,
pubmed-meshheading:11463303-Molecular Mimicry,
pubmed-meshheading:11463303-Peptides,
pubmed-meshheading:11463303-Predictive Value of Tests,
pubmed-meshheading:11463303-Protease Inhibitors,
pubmed-meshheading:11463303-Protein Conformation,
pubmed-meshheading:11463303-Structure-Activity Relationship
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| pubmed:year |
2001
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| pubmed:articleTitle |
Aspartic protease inhibitors designed from computer-generated templates bind as predicted.
|
| pubmed:affiliation |
School of Pharmacy, University of Wisconsin-Madison, 777 Highland Avenue, Madison, Wisconsin 53705, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|