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pubmed:abstractText |
A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, auto-immune, and allergic disorders.
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pubmed:affiliation |
Department of Chemistry, Celltech R&D, Inc., 1631 220th Street SE, 98021, Bothell, WA, USA. neil.cutshall@celltechgroup.com
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