11459653

Source:http://linkedlifedata.com/resource/pubmed/id/11459653

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003289, umls-concept:C0079411, umls-concept:C0162758, umls-concept:C2603343
pubmed:issue	14
pubmed:dateCreated	2001-7-18
pubmed:abstractText	A series of indolylcyclohexylamines possessing potent and selective serotonin reuptake inhibition is reported. The most interesting compounds proved to have subnanomolar 5-HT transporter activity, and exhibited moderate 5-HT(1A) affinity.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexylamines, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1, http://linkedlifedata.com/resource/pubmed/chemical/SLC6A4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane..., http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Uptake Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Slc6a4 protein, rat
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0960-894X
pubmed:author	pubmed-author:AbulhawaSS, pubmed-author:AndreeT HTH, pubmed-author:EvrardD ADA, pubmed-author:MeagherK LKL, pubmed-author:MewshawR ERE, pubmed-author:ScerniRR, pubmed-author:SchechterL ELE, pubmed-author:ShiXX, pubmed-author:SmithD LDL, pubmed-author:SpanglerTT, pubmed-author:ZhouPP
pubmed:issnType	Print
pubmed:day	23
pubmed:volume	11
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1885-8
pubmed:dateRevised	2005-11-17
pubmed:meshHeading	pubmed-meshheading:11459653-Animals, pubmed-meshheading:11459653-Antidepressive Agents, pubmed-meshheading:11459653-CHO Cells, pubmed-meshheading:11459653-Carrier Proteins, pubmed-meshheading:11459653-Cricetinae, pubmed-meshheading:11459653-Cyclohexylamines, pubmed-meshheading:11459653-Humans, pubmed-meshheading:11459653-Indoles, pubmed-meshheading:11459653-Inhibitory Concentration 50, pubmed-meshheading:11459653-Membrane Glycoproteins, pubmed-meshheading:11459653-Membrane Transport Proteins, pubmed-meshheading:11459653-Nerve Tissue Proteins, pubmed-meshheading:11459653-Rats, pubmed-meshheading:11459653-Receptors, Adrenergic, alpha, pubmed-meshheading:11459653-Receptors, Serotonin, pubmed-meshheading:11459653-Receptors, Serotonin, 5-HT1, pubmed-meshheading:11459653-Serotonin Plasma Membrane Transport Proteins, pubmed-meshheading:11459653-Serotonin Uptake Inhibitors, pubmed-meshheading:11459653-Structure-Activity Relationship
pubmed:year	2001
pubmed:articleTitle	Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.
pubmed:affiliation	Global Chemical Sciences and Neuroscience Departments, Wyeth-Ayerst Research Laboratories, CN 8000, NJ 08543-8000, Princeton, USA.
pubmed:publicationType	Journal Article