rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2001-7-18
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pubmed:abstractText |
The synthesis of four benzophenone-containing analogues of the antiproliferative natural product didemnin B is presented. In vitro protein biosynthesis inhibition potency and antitumor activity were evaluated. The results indicate that all four analogues are biologically active and could serve as photoaffinity reagents for the study of receptor-binding interactions of didemnins. These analogues could also be useful in studying antitumor effects of didemnins.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzophenones,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Depsipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Elongation Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Photoaffinity Labels,
http://linkedlifedata.com/resource/pubmed/chemical/benzophenone,
http://linkedlifedata.com/resource/pubmed/chemical/didemnins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0960-894X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1871-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11459650-Antineoplastic Agents,
pubmed-meshheading:11459650-Benzophenones,
pubmed-meshheading:11459650-Biological Factors,
pubmed-meshheading:11459650-Carrier Proteins,
pubmed-meshheading:11459650-Cell Division,
pubmed-meshheading:11459650-Depsipeptides,
pubmed-meshheading:11459650-Humans,
pubmed-meshheading:11459650-Inhibitory Concentration 50,
pubmed-meshheading:11459650-Peptide Elongation Factor 1,
pubmed-meshheading:11459650-Peptides, Cyclic,
pubmed-meshheading:11459650-Photoaffinity Labels,
pubmed-meshheading:11459650-Protein Biosynthesis,
pubmed-meshheading:11459650-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Synthesis and biological evaluation of didemnin photoaffinity analogues.
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pubmed:affiliation |
Department of Chemistry, University of Pennsylvania, 19104-6323, Philadelphia, PA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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