Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-7-18
pubmed:abstractText
There is increasing evidence that hematopoietic stem cell mobilization and homing is regulated not only by adhesion molecules and cytokines, but also by chemotactic factors that support transendothelial migration across the bone marrow sinusoidal endothelium. Many receptors for chemotactic mediators belong to the family of G protein-coupled seven-transmembrane receptors (7-TMR). Signaling via G proteins, particularly Gi proteins, results in a chemotactic response of the cells towards a gradient of the corresponding ligand. Recent studies have provided evidence for expression of several 7-TMR on immature hematopoietic progenitor cells, which potentially mediate chemotactic effects: chemokine receptors (e.g., CXCR4, receptor for stromal cell-derived factor-1), receptors for lipid mediators (e.g., the cysteinyl leukotriene receptor cysLT1 and the peripheral cannabinoid receptor cb2), and receptors for neuroendocrine hormones (e.g., the somatostatin receptor sst2). From these studies it can be concluded that migration of hematopoietic progenitor and stem cells is controlled by a variety of chemotactic factors rather than by a single chemokine (e.g., SDF-1). Trafficking of immature hematopoietic cells may require combined and interactive regulatory functions of these mediators.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12, http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC, http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors, http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene D4, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Octreotide, http://linkedlifedata.com/resource/pubmed/chemical/Polyunsaturated Alkamides, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cannabinoid, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Formyl Peptide, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukotriene, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Peptide, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatostatin, http://linkedlifedata.com/resource/pubmed/chemical/Somatostatin, http://linkedlifedata.com/resource/pubmed/chemical/anandamide, http://linkedlifedata.com/resource/pubmed/chemical/cysteinyl leukotriene receptor 2, http://linkedlifedata.com/resource/pubmed/chemical/leukotriene D4 receptor, http://linkedlifedata.com/resource/pubmed/chemical/somatostatin receptor 2
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
938
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
26-34; discussion 34-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11458515-Arachidonic Acids, pubmed-meshheading:11458515-Bone Marrow, pubmed-meshheading:11458515-Calcium Signaling, pubmed-meshheading:11458515-Cell Movement, pubmed-meshheading:11458515-Chemokine CXCL12, pubmed-meshheading:11458515-Chemokines, CXC, pubmed-meshheading:11458515-Chemotactic Factors, pubmed-meshheading:11458515-Endothelium, pubmed-meshheading:11458515-GTP-Binding Proteins, pubmed-meshheading:11458515-Hematopoietic Stem Cells, pubmed-meshheading:11458515-Leukotriene D4, pubmed-meshheading:11458515-Membrane Proteins, pubmed-meshheading:11458515-Multigene Family, pubmed-meshheading:11458515-Octreotide, pubmed-meshheading:11458515-Polyunsaturated Alkamides, pubmed-meshheading:11458515-Protein Structure, Tertiary, pubmed-meshheading:11458515-Receptors, CXCR4, pubmed-meshheading:11458515-Receptors, Cannabinoid, pubmed-meshheading:11458515-Receptors, Drug, pubmed-meshheading:11458515-Receptors, Formyl Peptide, pubmed-meshheading:11458515-Receptors, Immunologic, pubmed-meshheading:11458515-Receptors, Leukotriene, pubmed-meshheading:11458515-Receptors, Peptide, pubmed-meshheading:11458515-Receptors, Somatostatin, pubmed-meshheading:11458515-Somatostatin, pubmed-meshheading:11458515-Structure-Activity Relationship
pubmed:year
2001
pubmed:articleTitle
Transendothelial migration of hematopoietic progenitor cells. Role of chemotactic factors.
pubmed:affiliation
Dept. of Medicine II, University of Tübingen, Otfried-Müller-Str. 10, 72076 Tübingen, Germany. robert.moehle@med.uni-tuebingen.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't